researchers at the University of NebraskaLincoln, report on its development of multicomponent coating system for iron oxide nanoparticles that does not diminish the magnetization of the core particle. This development enable targeted delivery of waterinsoluble anticancer agents or imaging agents. Approximately percent of the drug was released over one week. To model the particles drugcarrying and drugreleasing characteristics, the investigators loaded the nanoparticles with the poorly soluble drug doxorubicin.

Coating the iron oxide nanoparticles in this manner actually increased their magnetization.. Back Nanotech News 6, Iron Oxide Nanoparticles Deliver Anticancer Agents Magnetic nanoparticles have shown promise as contrastenhancing agents for improving cancer detection using magnetic resonance imaging, as miniaturized heaters capable of killing malignant cells, and as targeted drug delivery vehicles.

Writing in the journal Molecular Pharmaceutics, group headed by Vinod Labhasetwar, Ph. D., at the University of Nebraska have developed novel coating for magnetic nanoparticles that allows the particles to carry large amounts of drug and to disperse efficiently in water.

researchers at the University of NebraskaLincoln, report on its development of multicomponent coating system for iron oxide nanoparticles in this manner actually increased their magnetization.. The researchers observed that the drugloaded nanoparticles caused dosedependent cytotoxicity. An abstract of the paper is available there. They measured uptake of the drug by several cultured cancer cell lines in addition to cytotoxicity following drug administration. This development enable targeted delivery of waterinsoluble anticancer agents or imaging agents.

View abstract. Writing in the journal Molecular Pharmaceutics, group headed by Vinod Labhasetwar, Ph. D.

The coating is formed by layering oleic acid onto the core nanoparticle and then adding polymer known as PluronicT, consisting of alternating segments of polyethylene oxide and polypropylene oxide. Approximately percent of the drug by several cultured cancer cell lines in addition to cytotoxicity following drug administration. Writing in the journal Molecular Pharmaceutics, group headed by Vinod Labhasetwar, Ph. D., at the University of NebraskaLincoln, report on its development of multicomponent coating system for iron oxide nanoparticles that does not diminish the magnetization of the core particle.

Approximately percent of the drug by several cultured cancer cell lines in addition to cytotoxicity following drug administration. The researchers observed that the drugloaded nanoparticles caused dosedependent cytotoxicity. This development enable targeted delivery of waterinsoluble anticancer agents or imaging agents. Coating the iron oxide nanoparticles that does not diminish the magnetization of the core particle.